WebJun 6, 2014 · AKT is then recruited to the cell membrane through interaction between its pleckstrin homology (PH) domain and PtdIns(3,4,5)P3, where AKT is phosphorylated at two critical residues, Thr308/309 in the activation T loop and Ser473/474 in the hydrophobic domain of AKT1/2 (unless designated otherwise, phosphorylation sites are based on the … WebJan 24, 2024 · Phospho-Akt is crucial to increase glycolysis under hypoxia. In search for the kinase we used various inhibitors and analyzed phospho-Akt by Western analysis. First, mTOR and Akt were inhibited by Torin-2 and AKTVIII, while DMSO served as a control (Fig. 3 a, b). DMSO allowed hypoxia to phosphorylate of Akt at Thr308 but not Ser473.
(9275) Phospho-Akt (Thr308) Antibody - CiteAb
WebMore>> Detect phospho-Akt (Thr308) using this Anti-phospho-Akt (Thr308) Antibody, clone 50-1C-25 validated for use in WB, IF, IC, ELISA. Less<< MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. WebAkt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 and by phosphorylation within the carboxy terminus at Ser473. Phospho-Akt promotes cell survival by inhibiting apoptosis. Specifically, phospho-Akt1 has been shown to phosphorylate Bad, a member of the Bcl-2 family that promotes cell death. optex xwave hybrid outdoor 30m dual beam
Right-To-Left Ventricular Differences in the Expression of ...
Web(9275) Phospho-Akt (Thr308) Antibody Supplier Cell Signaling Technology. Host Rabbit Type Primary Clonality Polyclonal Conjugate Unconjugated Target RAC-alpha … WebThe Phospho-AKT (Thr308) kit is designed for robust quantification of AKT modulation, phosphorylated on Thr308 across all isoforms (AKT1/2/3). Also known as protein kinase B (PKB), AKT is an oncogene playing a key role in controlling apoptosis, cell proliferation, transcription, cell migration, and glucose metabolism. WebCell Signaling Technology's Phospho-Akt (Thr308) Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Precipitation, … porthcawl surf camera