High theophylline levels

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August undefined, 2024

WebMany factors affect the rate of theophylline metabolism. Concentrations are increased in heart failure, cirrhosis, viral infections and in the elderly, and decreased in smokers, … WebSixty patients with theophylline toxicity were hospitalized during a 2-year period. Eleven patients had hypercalcemia; their calcium levels returned to normal as theophylline levels …

Theophylline – Health Information Library PeaceHealth

WebFeb 10, 2024 · The reference therapeutic ranges of theophylline are listed below. Reference ranges of theophylline in the treatment asthma vary by age, as follows: Adults: 5-15 µg/mL. Children: 5-10 µg/mL. The... The assessment and diagnosis of exercise-induced bronchoconstriction is made … notion schule template

Theophylline monitoring – SPS - Specialist Pharmacy Service – …

WebAug 31, 2024 · High-risk cases include the following: Acute overdose with theophylline levels higher than 80 mcg/mL Chronic toxicity with levels higher than 40 mcg/mL Patients … WebJul 26, 2024 · Too high: 20 to 25 µg/mL: Decrease doses by about 10% and recheck serum level after 3 days. 25 to 30 pg/mL: ... Serum levels should be monitored periodically to determine the theophylline level associated with observed clinical response and to identify the potential for toxicity. For such measurements, the serum sample should be obtained … WebNov 3, 2024 · Haemodialysis (if possible charcoal haemoperfusion is the modality of choice). Indications for dialysis include: Theophylline level … how to share oracle certification on linkedin

Chronic obstructive pulmonary disease: Theophylline

WebOct 4, 2024 · In patients with theophylline overdose who are at high risk for theophylline-induced seizures, e.g., patients with acute overdoses and serum theophylline concentrations > 100 mcg/mL or chronic overdosage in patients > 60 years of age with serum theophylline concentrations > 30 mcg/mL, the need for anticonvulsant therapy should be anticipated ... WebNo food or liquid (other than water) was allowed for 4 hours after which a standard lunch was served. Mean peak theophylline serum levels (C max) was 6.69 mcg/mL and mean … notion search shortcutWebPurpose: To evaluate prospectively whether serum theophylline concentrations of 25 mg/L and greater were predictable (and presumably preventable) by use of basic pharmacokinetic calculations. Design: Prospective study. Patients: Fifty-five patients with a serum theophylline concentration of at least 25.0 mg/L were evaluated initially and if subsequent … notion search engine indexing

"WebTheophylline metabolism can be altered by a variety of abnormal physiologic states as well as by exogenous factors. Adult studies demonstrate a significant influence of dietary composition on theophylline biotransformation. ... Compared to the normal diet, high protein diet markedly decreased the half-life, and high carbohydrate diet greatly ... " - High theophylline levels

High theophylline levels

WebMar 22, 2024 · Theophylline: Although causality has not been established, concurrent use of pentoxifylline with theophylline has resulted in elevated theophylline plasma levels, which may enhance the possibility of adverse effects. Drug-Food Interactions. Interactions with food have not been established. Drug-Herb Interactions WebIn most individuals, a plasma-theophylline concentration of 10–20 mg/litre (55–110 micromol/litre) is required for satisfactory bronchodilation, although a lower plasma …

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WebJun 30, 2024 · Adults are may be given about 300-600mg of Theophylline per day depending on their condition. This amount is equivalent to the therapeutic dose which is between 10-20mg/L. If the amount of 25mg/L, it … WebMar 1, 2024 · At serum Theophylline concentrations > 20 mcg/mL, both the frequency and severity of adverse reactions increase. In general, maintaining peak serum Theophylline concentrations between 10 mcg/mL and 15 …

WebJun 20, 2024 · High blood sugar (increased thirst, increased urination, hunger, dry mouth, drowsiness, blurred vision, weight loss) ... Low levels of theophylline and caffeine may indicate that the drug has not reached a therapeutic level for the individual tested and there is insufficient drug present to be effective. WebApr 1, 2024 · fast, slow, or irregular heartbeat increase in urine volume lightheadedness persistent vomiting pounding or rapid pulse seizures shakiness Get emergency help …

WebTherapeutic levels: 4 to 12 mcg/ml [SI: 17 to 51 micromole/L] Note: 4 to 8 mcg/mL if patient is receiving other anticonvulsants. Half-life: 8 - 60 hours in adults Epoxide metabolite: 25 to 43 hours (active metabolite) Time to … WebTheophylline levels may be modestly altered in thyroid dysfunction. In hyperthyroidism, theophylline metabolism is increased, and therefore the dose may need to be reduced as thyroid levels are corrected. Conversely, patients with hypothyroidism may need the dose of theophylline increased as treatment with levothyroxine or liothyronine continues.

WebTheophylline levels In most individuals a plasma theophylline of between 10-20mg/litre is required for satisfactory bronchodilation; however, a lower plasma theophylline …

WebHigh blood theophylline levels can lead to symptoms of toxicity (see below). Therefore, theophylline blood levels are monitored periodically during treatment to assure achievement of optimal and safe levels. The initial dose is 300-600 mg once daily or as a divided dose for 3 days. The maintenance dose is 400-600 mg daily. notion search databaseWebFeb 26, 2013 · Theophylline increases histone deacetylase-2 (HDAC2) via inhibition of phosphoinositide-3-kinase-δ (PI3Kδ), which is activated by oxidative stress to phosphorylate and reduce HDAC2. HDAC2 deacetylates core histones that have been acetylated by the histone acetyltransferase (HAT) activity of coactivators, such as CREB-binding protein … how to share opportunities in salesforceWebToo much theophylline can be life-threatening. Symptoms of too much theophylline include: Vomiting, heartburn, and belly pain. Rapid heart rate or other changes in heart rhythm. … notion search barWebJan 14, 2024 · Check with your doctor immediately if any of the following side effects occur while taking theophylline: Incidence not known Chest pain or discomfort dizziness fainting fast, slow, or irregular heartbeat increase in urine volume lightheadedness persistent vomiting pounding or rapid pulse seizures shakiness how to share order details in amazonWebSymptoms usually manifest if serum theophylline level 20-25 mg/L 1, 2. Symptoms increase in frequency and severity with increasing levels (significant individual variability exists … notion second windowWebSafe levels for people taking theophylline are often 8 to 20 mcg/mL. Levels above 20 mcg/mL may be harmful and can happen if people take too many pills within a short time period. Such cases might include accidentally taking extra pills or having a prescription that was written for too high a dose. how to share other calendars in googleWebTHEOPHYLLINE AS A BRONCHODILATOR. Traditionally, theophylline was used as a bronchodilator in the treatment of airway disease but, to achieve significant bronchodilatation comparable with that of a β 2 agonist, relatively high plasma concentrations are needed (10–20 mg/l). Theophylline relaxes human airway smooth … how to share other ig stories on mine