Cyp17a1蛋白
WebCYP17A1 is on Chromosome 15q23 and codes a 57 kDa enzyme that catalyzes two oxidase reactions resulting in a hydroxylation and a cleavage (lyase activity). The zone … WebFunction. A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis ( PubMed: 9452426, PubMed: 27339894, PubMed: 22266943, PubMed: 25301938 ). Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an …
Cyp17a1蛋白
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CYP17A1 is a 57.4 kDa protein that belongs to the cytochrome P450 family. The protein encoded by its cDNA is composed of 508 amino acid residues. As an enzyme, CYP17A1 possesses an active site that associates with a heme prosthetic group to catalyze biosynthetic reactions. See more Cytochrome P450 17A1 (steroid 17α-monooxygenase, 17α-hydroxylase, 17-alpha-hydroxylase, 17,20-lyase, 17,20-desmolase) is an enzyme of the hydroxylase type that in humans is encoded by the … See more Gene The CYP17A1 gene resides on chromosome 10 at the band 10q24.3 and contains 8 exons. The cDNA of this gene spans a length of 1527 bp. This gene encodes a member of the cytochrome P450 superfamily … See more CYP17A1 is a member of the cytochrome P450 superfamily of enzymes localized in the endoplasmic reticulum. Proteins in this family are monooxygenases that catalyze synthesis of cholesterol, steroids and other lipids and are involved in drug metabolism. CYP17A1 has both … See more • Pregnenolone • 17α-Hydroxypregnenolone • Progesterone • 17α-Hydroxyprogesterone See more Expression of CYP17A1 has been found in all of the traditional steroidogenic tissues except the placenta, including the zona reticularis and zona fasciculata of the adrenal cortex, the Leydig cells of the testes, the thecal cells of the ovaries, and, more recently, in See more Mutations in this gene are associated with rare forms of congenital adrenal hyperplasia, specifically 17α-hydroxylase deficiency/17,20-lyase deficiency and isolated 17,20-lyase deficiency See more CYP17A1 inhibitors Currently, the FDA has approved only one CYP17A1 inhibitor, abiraterone, which contains a steroidal … See more 细胞色素 P450 17A1（英語：Cytochrome P450 17A1）也被称为甾体17α-单加氧酶（steroid 17α-monooxygenase），17α-羟基化酶（17α-hydroxylase），17,20-碳链裂解酶（17,20-lyase 或 17,20-desmolase）是一种羟基化酶，由位于人类10号染色体的 CYP17A1 基因编码 。这一基因在许多组织与细胞中都有表达，特别是肾上腺皮质的网状带（英语：zona reticularis）和 …
WebMar 21, 2024 · CYP11A1 (Cytochrome P450 Family 11 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP11A1 include Adrenal Insufficiency, Congenital, With 46,Xy Sex Reversal, … Webcyp17a1 是阿比特龙的主要靶标，阿比特龙是一种用于治疗去势抗性前列腺癌 (crpc) 的合成类固醇 (3, 4)。 阿比特龙可转化为更具活性的 D4A，D4A 通过抑制 CYP17A1 和其他类固醇激素合成酶来抑制雄激素受体信号转导 …
Web抗cyp17a1抗体(d-12)在各种科学出版物中有12篇引文。 针对哺乳动物靶标蛋白的一抗，如抗cyp17a1 抗体 (d-12)，推荐用于检测一系列哺乳动物物种，主要有小鼠，大鼠和人物种。 许多哺乳动物抗体也非常适合兽医研究，与羊、猪、羊、猫、犬、牛和马的蛋白靶点反应。 Web发明领域. 本发明涉及制备苯并咪唑化合物，其用作p300和/或CBP活性调节剂和因此能够用作药物物质。 发明背景
WebCYP17A1 ( シトクロム P450 17A1, steroid 17-alpha-monooxygenase 17α-hydroxylase/17,20 lyase/17,20 desmolase) はヒトにおいて CYP17A1 遺伝子がコードす …
WebER stress增加PERK蛋白激酶活性，PERK磷酸化elF2，抑制蛋白翻译和合成，缓解ER压力。同时，elF2的磷酸化能够选择性地启动ATF4翻译，增加其结合配体的合成，影响氨基酸代谢，从而抑制蛋白的翻译和合成[6]。 正常 … florist in cookeville tennesseehttp://www.delta-f.com/highchemical/protac%20linker?page=7550 florist in concord township ohiohttp://www.jinpanmed.cn/archives/date/2024/04/11 florist in coolidge azWebDefects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5) [MIM:202410]. AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to … florist in coon rapids iaWeb作为胆汁酸合成限速酶, cyp7a1的表达受饮食因素的调控. 日本研究者发现在7周龄的sd雄性大鼠中, 给予乳酸发酵的豆奶饲食5 wk后, rt-pcr显示肝组织中cyp7a1的mrna表达较对照 … florist in cornwall on hudson nyWeb摘要： 第一部分类固醇生成因子1(SF-1)在孕期镉暴露抑制F1代大鼠睾酮合成中的作用及其表观遗传机制研究目的:探究孕期镉暴露对F1代大鼠睾丸发育及类固醇激素合成的影响,以及SF-1调控类固醇激素合成相关因子表达在孕期镉暴露影响F1代大鼠睾酮合成中作用及其表观遗传机制.方法:将40只成年SD孕鼠 ... florist in cornish maineWebDec 1, 2024 · Cyp17a1 (Cytochrome P450 family 17 subfamily A member 1) is thought to play essential roles in fish steroidogenesis. Therefore, to further understand its roles in steroidogenesis, sex determination, and fertility in fish, we constructed a cyp17a1 gene mutant in Nile tilapia (Oreochromis niloticus). In XX fish, mutation of the cyp17a1 gene … florist in corryton tn