Cthrc1 kda

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August undefined, 2024

WebImmunohistochemistry-Paraffin: CTHRC1 Antibody [NBP2-31797] - Staining of human pancreas shows low positivity in glandular cells as expected. Immunohistochemistry-Paraffin: CTHRC1 Antibody [NBP2-31797] - Staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells. WebApr 17, 2024 · CTHRC1 has four different isoforms with molecular weights of about 12.3 kDa to 27 kDa; the full-length of CTHRC1 accounts for both secreted and cellular CTHRC1 . Glycosylated protein CTHRC1 with a …

Regulation of CTHRC1 expression. A and B. Western …

WebCTHRC1 was immunoprecipitated from 0.35 mg SK-MEL-28 (Human malignant melanoma) whole cell lysate with ab256458 at 1/30 dilution (2ug in 0.35mg lysates). Western blot was performed on the immunoprecipitate using ab256458 at 1/1000 dilution. VeriBlot for IP Detection Reagent (HRP) was used at 1/5000 dilution. WebCthrc1 is a 30 kDa secreted protein that has the ability to inhibit collagen matrix synthesis. Cthrc1 is also glycosylated and retains a signal sequence … We recently identified collagen triple helix repeat containing-1 (Cthrc1) as a novel gene induced in adventitial fibroblasts after arterial injury. brice laval

Collagen triple helix repeat containing 1 (CTHRC1) …

WebFeb 8, 2024 · Collagen triple helix repeat containing 1 (CTHRC1) is an extracellular matrix protein that regulates tumor invasion and modulates the tumor microenvironment. However, the association of CTHRC1 with the prognosis and tumor-infiltrating lymphocytes of KIRP and KIRC has not been reported. WebProteolytic processing may generate multiple CTHRC1 isoforms. There is the potential for an intracellular full-length 33 kDa, 245 aa form, plus extracellular isoforms that are 28 kDa (aa 33-245), 26 kDa (aa 49-245), 20 kDa (aa 98‑245) and 18 kDa and 16 kDa in size, the last two representing variants of the 20 kDa form with C-terminal processing. Web30.5 kDa: Protein Length: Full Length of Mature Protein: Tag Info: ... CTHRC1 is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. PMID: 15618538; Aberrant expression of CTHRC1 is widely present in human solid ... brice koons

CTHRC1 (E6W2E) Rabbit mAb Cell Signaling Technology

Expression analysis of the novel gene collagen triple helix repeat ...

WebCTHRC1 is a secreted 30 kDa glycoprotein that is highly conserved among vertebrates. The protein contains a N-terminal hydrophobic signal peptide that directs CTHRC1 for secretion, a short collagen triple helix repeat (CTHR) domain consisting of 12 repeats of the Gly-X-Y motif [11], and a WebAnti-CTHRC1 antibody [EPR22851-145] (ab256458) Research with confidence – consistent and reproducible results with every batch. Long-term and scalable supply – powered by recombinant technology for fast production. Success from the first experiment – confirmed specificity through extensive validation. Ethical standards compliant ... brice krupaWebMay 22, 2024 · Collagen triple helix repeat containing 1 (CTHRC1), a secreted ECM protein, is a 28-kDa evolutionarily conserved extracellular matrix glycoprotein, containing an NH2-terminal signaling peptide for extracellular secretion, a short collagen triple helix repeat of 36 amino acids, and a COOH-terminal globular domain . brice koh lanta poids

"WebCTHRC1 protein expression summary. Single band larger than predicted size in kDa (+20%) but partly supported by experimental and/or bioinformatic data. " - Cthrc1 kda

Cthrc1 kda

CTHRC1 expression is a novel shared diagnostic and …

WebCTHRC1 is specifically expressed in vascular calcifications of carotid artery lesions and may contribute to vascular remodeling of injured arteries (Pyagay et al., 2005 [PubMed 15618538]).[supplied by OMIM] WebCollagen triple helix repeat containing protein 1 (CTHRC1) is a 30 kDa secreted glycoprotein encoded by the CTHRC1 gene. CTHRC1 is known to regulate extracellular collagen deposition and partake in vascular remodeling of arterial injury as a function of cellular response through the TGF-β and Wnt pathways. Moreover,

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WebAug 12, 2024 · CTHRC1 expresses mainly in adventitial fibroblasts and neointimal smooth muscle cells of balloon-injured vessels and promotes cell migration and tissue repair in response to injury. CTHRC1 plays a ... WebOct 11, 2024 · Background Metastasis is the major cause of morbidity and mortality in patients with epithelial ovarian cancer (EOC), however the mechanisms that underline this process are poorly understood. Collagen triple helix repeat containing-1 (CTHRC1) is a 28-kDa secreted protein reported to be involved in vascular remodeling, bone formation …

WebCTHRC1, a 28-kDa secreted ECM protein, could promote cell migration via limiting collagen matrix deposition [16]. ... (TAMs) is associated with tumor progression and poor prognosis in endometrial ... WebMay 19, 2014 · The gene that coded for collagen triple helix repeat containing 1 (CTHRC1), located at chromosome 8q22.3, was overexpressed in HCC compared with normal or liver cirrhosis tissues and identified as a new HCC-related gene. ... Fig. 1D shows that the 26-kDa CTHRC1 protein was expressed in membrane fractions of the HepG2 …

WebCollagen triple helix repeat containing-1 (CTHRC1) is a 28-kDa secreted protein, reported to be involved in vascular remodeling, bone formation and morphogenesis [19]. In addition to functioning in the context of arterial injury, recent studies have reported CTHRC1 acts as a prognostic factor. Furthermore, it promotes tumor WebMar 1, 2005 · Collagen triple helix repeat containing 1 (CTHRC1) is a 28-kDa secreted glycoprotein containing a short collagen motif with 12 Gly-X-Y repeats, and it is highly conserved from lower chordates to ...

WebThe molecular weight of secreted CTHRC1 (30 kDa) appears to be larger than that of cellular CTHRC1 (26 kDa). CTHRC1 has four different isoforms with molecular weights of about 12.3 kDa to 27 kDa ...

Web25.3 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. ... There are no reviews for CTHRC1 Recombinant Protein (NBP2-52008). By submitting a review you will ... target 1300 w lake st minneapolisWebCollagen triple helix repeat containing 1: Protein class i. Disease related genes Human disease related genes: Predicted location i. Intracellular,Secreted ... 26.2 kDa Yes: 0: CTHRC1-202 ENSP00000416045 ENST00000415886: E7EVQ5 [Direct mapping] Collagen triple helix repeat-containing protein 1 . Show all. brice kuurneWebAll lanes : Anti-CTHRC1 antibody (ab264411) at 1/1000 dilution Lane 1 : UACC-62 whole cell lysate Lane 2 : MALME-62 whole cell lysate Lane 3 : SR whole cell lysate Lane 4 : NIH/3T3 (mouse embryo fibroblast cell line) whole cell lysate Lysates/proteins at 50 µg per lane. Developed using the ECL technique. Predicted band size: 26 kDa Exposure time: … brice makniWebThe recombinant human CTHRC1 consists of 224 amino acids and has a predicted molecular mass of 24.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh CTHRC1 is approximately … brice kopas mdWebAll lanes : Anti-CTHRC1 antibody (ab264410) at 1/1000 dilution Lane 1 : UACC-62 whole cell lysate Lane 2 : MALME-3M whole cell lysate Lane 3 : SR whole cell lysate Lane 4 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate Lysates/proteins at 50 µg per lane. Developed using the ECL technique. Predicted band … bric eligible projects brice lane jekyll island gaWebCTHRC1 is overexpressed in multiple human cancers, and its expression is associated with increased migration and metastasis, as well as decreased survival (1-3). CTHRC1 expression is regulated through TGF-β/Smad3 … brice nankpan